Lysosomal transport of cystine and other small molecules.
نویسندگان
چکیده
Goldman, R. & Kaplan, A. (1973) Biochim. Bwphys. Acru 318,205216 Harikumar, P. & Reeves, J. P. (1983) J . Bid. Chem. 258, 1040310410 Jonas, A. J., Smith, M. L., Allison, W. S., Laikind, P. K., Greene, A. A. &Schneider, J . A. (1983) J . Bwl. Chem. 258,11727-11730 FEBS Letr. 149, 71-74 Merion, M., Schlesinger, P., Brooks, R. M., Moehring, J. M., Moehring, T. J. & Sly, W. S. ( 1 983) Proc. Natl. Acud. Sci. US. A .
منابع مشابه
The transport systems of mammalian lysosomes.
X. Amino acid transport systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354 A. Lysosomal cystine transport and cystinosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354 B. The cystine dimc~[~,yl esle~ selection technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 356 C. Cationic ami...
متن کاملLysosomal cystine transport. Effect of intralysosomal pH and membrane potential.
The regulation of lysosomal cystine transport was studied using cystine dimethyl ester-loaded lysosomes isolated from human diploid fibroblasts. Net efflux from normal fibroblast lysosomes was compared to that from lysosomes of cystinotic fibroblasts, which contain an inherited mutation decreasing lysosomal cystine transport. This exodus of cystine from normal fibroblast lysosomes was greater t...
متن کاملCharacteristics of cystine counter-transport in normal and cystinotic lysosome-rich leucocyte granular fractions.
Normal leucocyte lysosome-rich granular fractions exhibited counter-transport of cystine, confirming that cystine transport across the lysosomal membrane is carrier-mediated. The trans-activation of cystine transport was temperature-dependent but relatively independent of the external Na+ or K+ concentration in phosphate buffer. Counter-transport, measured as uptake of exogenous [3H]cystine, in...
متن کاملDisruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration
Cystine and cysteine are important molecules for pathways such as redox signaling and regulation, and thus identifying cellular deficits upon deletion of the Saccharomyces cerevisiae cystine transporter Ers1p allows for a further understanding of cystine homeostasis. Previous complementation studies using the human ortholog suggest yeast Ers1p is a cystine transporter. Human CTNS encodes the pr...
متن کاملCRF fellow : Gennaro Napolitano
The aim of the project “Small molecule regulators of vesicular trafficking to enhance lysosomal exocytosis in cystinosis” is to use strategies directed at upregulating the exocytic pathway in cystinotic cells, in order to improve vesicular transport, force cystine release and restore normal cell function. Our hypothesis, in fact, states that cells that have accumulated cystine share the intrace...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 12 6 شماره
صفحات -
تاریخ انتشار 1984